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In a current study, we reported the identification and also the characterization of a completely new atypical opioid receptor with exceptional negative regulatory Homes toward opioid peptides.1 Our outcomes showed that ACKR3/CXCR7, hitherto generally known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can also be a wide-spectr